Chronic Rhinosinusitis’s with Nasal Polyps

Chronic Rhinosinusitis is a chronic disease that negatively affects the quality of life. When associated with nasal polyps, there is worsening of the condition, and it becomes harder to treat due to the high rates of recurrence and the increased morbidity rates. Though having a set treatment method, the condition still has unknown etiology and pathophysiology, which makes it extremely hard to diagnose and evaluate. Due to these unknown factors, treatment is still not as precise and effective; we still rely on systemic drugs like corticosteroids which most often do not resolve the disease, and we then present surgical options, though effective still do not pose as an effective cure, which may be a factor in the high rate of recurrences. However, there have been giant leaps in the specialized research of this particular topic, leading to classification through biomarkers allowing us to study and consolidate data on the disease pathology and all of the different options causing recurrences, which further enhances our understanding of how this disease affects a diverse population. The majority of the treatment given in this disease is not evidence-based but instead based on clinical observation and experience. Therefore, with CRSwNP, we are confronted with more questions than answers, which is problematic as the disease can often be associated with comorbidities leading to a further decrease in quality of life. Hence, this review article aims to aggregate and compile this valuable research and highlight the strides which have already been made while promoting additional research so that the disease can become more manageable without any recurrence.