STAT 3 Mutations, Giardia Infection and the IL-17 Pathway

Parasitic infections may be common in endemic areas. Giardia spp. infections are widespread and not endemic to one region. The combined presence of parasitic infections and high serum immunoglobulin level E (IgE) levels, can be found in isolation or as a clinical manifestation of certain immune defects.

The Hyper-IgE syndromes (HIES) as a group of distinct primary immune disorders should be considered in the differential and treatment of parasitic disease. The aim of this study was to highlight the importance of recognizing underlying immune defects in the clinical setting of parasitic infection, including HIES.