Advanced Colorectal Carcinoma Inspite of Initial Non-malignant Biopsies: The Critical Role of Multidisciplinary Evaluation and Repeat Biopsies

Colorectal cancer (CRC) poses significant diagnostic and management challenges due to its varied clinical presentations. This case report describes a 60-year-old male who presented with progressive rectal bleeding, substantial weight loss, and a protruding mass from the anus. Initial evaluations, including ultrasound and CT scans, indicated neoplastic involvement in the sigmoid colon and rectum. In contrast, initial histopathology revealed high-grade dysplasia in the sigmoid colon and a solitary rectal ulcer. Due to persistent clinical suspicion and input from a multidisciplinary team, repeat biopsies confirmed poorly differentiated adenocarcinoma of the rectum. The patient underwent palliative surgery and systemic chemotherapy, which led to significant symptom relief and partial disease stabilization. This case highlights the need for comprehensive diagnostic assessment and a multidisciplinary approach in managing advanced colorectal cancer, highlighting the critical role of repeat biopsies and integrated clinical expertise in ensuring accurate diagnosis and effective treatment.