POLYETHYLENE GLYCOL ANCHORED DEXIBUPROFEN FOR EXTENDED ANTI INFLAMMATORY ACTIVITY IN WISTER RATS

Dex-Ibuprofen–polyethylene glycol (PEG) conjugates (PEG-dex-Ibu) were systematized and their potential as an extended release method was explored. By esterification process in the presence of DCC and DMAP the PEG-Dex-Ibuprofen conjugates were made as of Ibuprofen and PEG with molecular weights of about 4000 Da. The PEG-dex-Ibu conjugates were characterized by FT-IR, 1H NMR, and DSC analysis. The solubility study in aqueous system exhibited an enhancement within the solubility of conjugates and the dissolution studies showed an accurate acid–base catalysis prototype reliant on the pH of the medium. This proved to be a fine chemical constancy in aqueous buffer solution of acidic medium and the comprehensive release performance was found in prodrug after 6 hours. These consequences disclose that the rate of hydrolysis for PEG4000-dex-Ibu, in the similar state is slower than supplementary. These results endorse that PEG-Dex-Ibu could be a proficient NSAID prodrug. From this we can know that it has extended the pharmacological effect.